General Search Example using the Acumenta Online Research Assistant™
A scientist is interested in the process of angiogenesis associated
with adenocarcinoma in the human gastro-intestinal tract. The scientist's
interest is specifically in research over the last ten years and is focused
on males from early adulthood to middle age (ages 19 to 64).
Here is the search in Acumenta:
- The researcher merely puts the following search words (each separated
by a space) in two boxes: (1) adenocarcinoma angiogenesis in the Acumenta
AND search box; and (2) colon esophag* rectum rectal colorectal in the
Acumenta OR search box. In addition, the researcher would select Male
from the Gender pulldown menu, the Adult and Middle Aged checkboxes
from the Age(s) pulldown menu and then run the search.
- At the same time this query would search other literature and databases
of interest to the researcher.
Alternatively, here is the search that the researcher would have to compose
directly on PubMed:
- colon[TIAB] OR esophag*[TIAB] OR rectum[TIAB] OR rectal[TIAB] OR colorectal[TIAB])
AND (adenocarcinoma[TIAB] AND angiogenesis[TIAB]) AND "male"[MH]
AND ("adult"[MH:noexp] OR "middle age"[MH]) AND
"1994/08/30 14:55"[DP] : "2004/08/30 14:55"[DP]
Gene Search Use Case using the Acumenta Online Research Assistant™
The leukemia tumor suppressor gene, RUNX1, is also known as AML1 and
other aliases. A search on PubMed on RUNX1 finds 197 abstracts, 87
of which would be missed if a scientist searches on AML1 instead
of RUNX1. Similarly, a search on PubMed for AML1 finds 914 abstracts.
A similar search using the Acumenta Gene Thesaurus™ yields 1024
abstracts, all relevant to the search query. This is because RUNX1
has 16 viable aliases that have been automatically incorporated into the
search from the Acumenta Gene Thesaurus™.
Here is the search in Acumenta:
- The researcher simply selects the gene RUNX1 (or AML1 or any one of
its other aliases such as CBFA2) from the Acumenta Gene Thesaurus™
and runs the search. Acumenta then automatically includes all appropriate
aliases in the query when the search is run.
Alternatively, to duplicate these results in a native PubMed search,
the researcher would have to enter the following complex Boolean expression
into the PubMed search box:
- ((runx1[TW]) OR (runt-related transcription factor 1 acute myeloid
leukemia 1 aml1 oncogene[TW]) OR (aml1[TW]) OR (amlcr1[TW]) OR (cbfa2[TW])
OR (pebp2a2[TW]) OR (pebp2ab[TW]) OR (runt-related transcription factor
1 isoform b[TW]) OR (runt-related transcription factor 1 isoform a[TW])
OR (aml1 oncogene[TW]) OR (acute myeloid leukemia 1 gene[TW]) OR (core-binding
factor runt domain alpha subunit 2[TW]) OR (runt-related transcription
factor 1[TW]) OR (pebp2-alpha-b[TW]) OR ("pebp2ab aml1/tel fusion
gene"[TW]) OR ("aml1/mds1 fusion gene"[TW])) AND (cbfa2[TW])
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