Literature Lab™ PLUS -- Get answers about your gene lists, fast.
Literature Lab™ PLUS performs a statistical analysis on the scientific literature as it relates to experimentally-derived gene lists. Using an untapped resource -- the PubMed literature record -- Literature Lab™ PLUS reveals unanticipated connections within gene sets, helping scientists generate hypotheses that further their research and open new lines of inquiry.
Literature Lab™ PLUS is the most powerful tool available for hypothesis generation using genomic data. It identifies significant associations in 19 domains of biology and biochemistry, including pathways, diseases, cell biology, chemicals/drugs, metabolites and more. The newest domain of analysis to be added to Literature Lab™ PLUS is endogenous metabolites located in the blood, extending Literature Lab's reach and helping to bridge the information gap between genotype and phenotype.
the Literature Lab™ PLUS Analysis.
The LPFs (log of the product of frequency) of the genes in the input set are computed with each of 78,000 terms in the Literature Lab database (including diseases, pathways, cell biology, metabolites, and more). This analysis is also run for each of 1,000 random gene sets (RGS). The LPFs for the input data set are compared to the 1,000 RGS and statistically significant associations unique to each gene list analyzed, are identified.
A Literature Lab™ PLUS analysis on 100 genes is equivalent to 2.4 billion manual searches.
ANALYSIS RESULTS ARE PRESENTED IN A POWERFUL VIEWER.
The Literature Lab™ PLUS Viewer is a point-and-click solution that quickly reveals the biological meaning of your gene set. Significantly associated pathways, diseases, chemicals, cell biology and other biological and biochemical dimensions are shown accompanied by the genes that drive each association, ranked by their impact. The Literature Lab™ analysis is 100% transparent -- one click takes you to the abstracts that drive each association. There is no more wondering why, how or from where your gene set enrichment results are produced. The Literature Lab™ database is constantly updated, assuring you that the enrichment of your gene set is based on the latest data.
Compare multiple gene sets.
The Literature Lab™ PLUS Viewer compares the results of multiple Literature Lab™ analyses. What are the biological similarities and differences between two gene sets? The answer is a few clicks away. Time or drug course data? Data from multiple tissue types?...The PLUS Viewer shows the trends, changes, peaks, and more across multiple gene sets.
USEFUL ASSOCIATIONS OBTAINED WITH A SINGLE CLICK
IL10 is one of the drivers of this gene list's association with the Acute Inflammatory Response Pathway. This image shows the results of a single-click request for genes associated in the literature with IL10 AND the Acute Inflammatory Response Pathway. Genes in the gene list are displayed in bold blue. Note that the LPF in this example is computed on the selected gene's association with the genes in the literature.
Functional insights, targets revealed.
Literature Lab™ runs a clustering analysis on the genes and the significantly associated terms to illuminate functional relationships among groups of genes in the gene set. Quickly make sense out of larger heterogeneous gene lists.
The Literature Lab™ clusters are interactive -- clicking on a cell instantly takes you to the abstracts for the gene and the term. There is no more wondering why, how or from where your gene set enrichment results are produced.